
Chicago Mpox Spike: Facts, Vaccine Dates & Quick Checks
Concise, fact-led section using city data and official guidance. Built for quick reading and action.
From CDPH case updates and clinic notices, Chicago recorded 104 mpox cases from June 1–Sept 30, 2025, with 55 in September. Since June 2022, totals in the city include ~1,450 cases, 86 hospitalizations, and 4 deaths. Event details below match the CDPH weekly brief and community partners.
Jun–Sep 2025
September
Since 2022
Hospitalized
What To Know (Tap to expand)
Mpox is a viral illness (Orthopoxvirus). Two clades exist: Clade I (Ia, Ib) and Clade II (IIa, IIb). The 2022 outbreak involved Clade IIb. No Clade I cases have been reported in Chicago.
Rash or sores with possible fever, chills, headache, fatigue, swollen lymph nodes, and muscle aches.
- Close, personal contact with an infected person
- Contact with clothing, bedding, or linens used by an infected person
- Respiratory secretions during prolonged face-to-face contact
Anyone can get mpox. Recent spread has occurred primarily among social networks of gay, bisexual, and same-gender-loving men, with greater risk for those with multiple or anonymous partners. Pregnant people can pass infection to a fetus or newborn.
From symptom onset until the rash heals and new skin forms. Typical duration: about 2–4 weeks.
October Vaccine Events (Chicago)
Onyx Medical & Wellness, 2247 E. 73rd St.
Center on Cottage Grove, 6323 S. Cottage Grove Ave.
Center on Cottage Grove, 6323 S. Cottage Grove Ave.
The JYNNEOS vaccine is a 2‑dose series (28 days apart). Optimal protection is reached ~2 weeks after the second dose.
60‑Second Check
Q1. Full protection from JYNNEOS is expected:
Q2. Typical contagious period lasts:
Q3. Transmission can occur via:
Related on Karmactive
Official / External
This section presented case totals for June–September 2025, event dates, transmission routes, symptom lists, and vaccination steps.