Scientists Discover Stress-Relief Neural Pathway in Mice at IISc Bengaluru

Govind Tekale Govind Tekale

Scientists at IISc Bengaluru map a neural pathway turning stress into pain relief.

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This discovery involves the lateral septum, hypothalamus, and brain stem nuclei.

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Inhibitory neurons activate during stress, reducing pain sensitivity in mice.

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Mice show increased pain tolerance when physically restrained

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Key researchers: Devangshu Shah, Pallavi Sharma, Rachit Agarwal, and Arnav Barik.

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Arnav Barik highlights the potential for new therapeutic approaches.

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Neurons in the lateral septum become highly active during escape attempts.

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This neural activity is necessary and sufficient for stress-induced analgesia.

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The study provides invaluable insights into stress and chronic pain connections.

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