ATR-258: First Pill That Preserves Muscle While Fighting Diabetes

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Scientists have created a pill that treats diabetes and obesity without the muscle loss common in popular weight loss drugs.

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ATR-258 works by mimicking exercise effects in your body - improving blood sugar control while preserving crucial muscle mass.

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1. People with diabetes lose muscle three times faster than others, creating a dangerous cycle that worsens their condition.

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Unlike Ozempic which works by controlling appetite, this new pill targets metabolism directly in your muscle cells.

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"Our results point to a future where we can improve metabolic health without losing muscle mass," says Professor Bengtsson from Stockholm University.

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The drug activates specific pathways in muscle cells that boost glucose uptake while avoiding the pathways causing unwanted side effects.

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Why does muscle matter? 30-50% of older diabetes patients experience moderate-to-severe muscle loss, increasing their risk of falls, disability and earlier death.

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Could this be exercise in pill form? ATR-258 delivers key benefits of physical activity by enhancing how muscles absorb and use glucose.

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Taken just once daily as a capsule, this treatment could be more convenient than injectable medications like Ozempic or Wegovy.

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What's next? Researchers will test ATR-258 alongside popular GLP-1 drugs to potentially offer both appetite control AND muscle preservation in one treatment approach.

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