New research finds mice on semaglutide lost about 10% lean mass, but most came from liver shrinkage—not muscles. Some muscles still weakened even when size stayed stable. The Cell Metabolism study by University of Utah researchers measured both body composition and muscle function in mice given semaglutide, the active ingredient in Ozempic and Wegovy. Lean mass includes non-fat tissues such as organs and skeletal muscle. The liver shrank by nearly half while skeletal muscles showed more modest reductions of about 6% on average. This matters because most routine body composition scans report total lean mass and do not directly separate … Continue reading Ozempic Muscle Study: Liver Shrinks 50% While Strength Declines Despite Stable Size